Evaluate the rationale use of nonsteroidal anti-inflammatory drugs (NSAIDs) in laborers/ heavy workers in Katsina central market Department: Biochemistry By: EmmyICT Project ID: 7634 Rating: (5.0) votes: 1Rate this project12345 Price:₦4000 Get the Complete MaterialAbstractNonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain and inflammation. However, conventional NSAIDs (e.g., Diclofenac, Meloxicam, Ibuprofen) can induce gastrointestinal (GI) upset and adverse events, especially peptic ulceration. To reduce this risk, gastro-protective agents are commonly co-prescribed with NSAIDs alternatively, cyclooxygenase (COX)-2 inhibitors (e.g., Etoricoxib, Celecoxib) are used, a new generation of NSAIDs claimed to cause fewer gastrointestinal adverse events. Co-prescription of COX-2 inhibitors with gastro-protective agents are recommended only in patients at high risk of GI disease, such as elderly patients (aged= 60 years), those using antiplatelet agents (e.g., Aspirin), or patients with a history of GI events. Commonly used gastro-protective agents are histamine H2-receptor antagonists (H2RAs, e.g., Ranitidine) and proton pump inhibitors (PPIs, e.g., Omeprazole, Pantoprazole, Esomeprazole, Lansoprazole). The H2RAs competitively antagonize the histamine effects at H2-receptors in the stomach to reduce the amount and concentration of gastric acid. PPIs suppress stomach acid secretion by specific inhibition of the H+/K± ATPase system found at the secretory surface of gastric parietal cells. Concomitant use of H2RAs and PPIs are recommended only in the treatment of gastro-oesophageal reflux disease (GORD)....Preview Download Preview +Other Biochemistry project topics and materials you might be interested in»Phytochemical and nutritive composition of fluted pumpkin»Determination of ascorbic acid in selected fruits mango, orange and pineapple using spectro-photometric method»Comparative evaluation of heavy metal loads in some selected soft drinks in Owerri, Imo state»Antilipidemic effect of water (H2O) extract of desmodium velutinum leaves on albino Wistar rats»The effect of water extract of cola nitida pod on lipoprotein concentrations of albino Wistar rats»Preliminary investigation on effects of burantashi extract on lipoproteins of albino male and female whistar rats»The extraction of manganese (iv) ion from aqueous media using 1-phethyl-3-methyl pyrazolone-5»Nutritive value, anti-nutrient and mineral composition of cashew nut (Anacardium Occidentale)»Evaluation of the immunomodulatory effect of oral administration of the methanol extract of gongronema latifolium (utazi) in wistar albino rats»Comparative study on the free radical scavenging potential of turmeric and beetroot»Phytochemicals and minerals analysis of rosary pea (Abrus Precatorious leaves)»Determination of total petroleum hydrocarbons in Niger river»Qualitative phytochemical and gas chromatography mass spectrometry GCMS of Nhexane extracted leaves of sabicea calycina»Hydrogen peroxide scavenging activities and reducing power of various fruits juice in Yenagoa»Charges in the concentration of nitric oxide in the serum gills brain liver and kidney of clarias gariepinus exposed to glyphosatebased herbicide